Experimental approaches for the investigation of innate immunity: The human innate immunity handbook

With new information on the innate immune pathways for cellular recognition, genetic The chapter, ‘Circulatory Pathology in Osteoarthritis’ is the most interesting chapter of this book as it clearly delineates the changes in the skeletal vascularity causing osteoarthritis of the hip, and application of DCE (dynamic contrast-enhanced)-MRI and PET scan for imaging. The next chapter elucidates the effect of mechanical loading causing a change in fluid flow of the musculoskeletal system, a unique concept to prevent and treat osteoporosis. The last chapter describes paediatric and adolescent disorders affected by a disturbance in the vascularity of proximal femur. In adolescents, traumatic hip dislocation and femoral neck fracture are pertinent where outcomes are primarily affected by the vascularity disturbance whilst in the paediatric age group, Perthes disease and slipped capital femoral epiphysis (SCFE) are the major ones. The explanation of the pathological changes in Perthes disease affecting the femoral head and their prevention by intervening at the appropriate time is commendable.